CA 125 Test (Cancer Antigen 125)

CA 125 is the Cancer Antigen 125 test and this laboratory test measures the level of CA 125 protein level in the blood. CA means cancer antigen but its level may increase in some conditions other than cancer.

Purpose of CA 125 Blood Test

1- Monitoring cancer treatment: CA 125 test is done regularly to monitor the treatment of patients who have ovarian cancer, CA 125 test helps your doctor to understand the success of treatment.
2- CA 125 test may be used for ovarian cancer screening: If any of your family member has ovarian cancer or her BRCA1 and BRCA2 tests are positive, your doctor may request you to have CA 125 test for a check up.
3- Determining if the cancer is relapsed : Increasing of CA 125 may be a sign of relaps of cancer.

CA 125 Normal Value

Levels under 35 U/mL means normal.

Preparation of CA 125 Test

Biotin (B7) vitamin should not be used 12 hours before the test.

High CA 125 Causes

If you have ovarian cancer, increased CA 125 level means the cancer progressed otherwise high CA125 values don’t mean ovarian cancer everytime, because this protein may increase because of some different reasons like;

ca 125 test
• Liver disease (cirrhosis, hepatitis)
• Pregnancy
• Diverticulitis
• Endometriosis
• Pelvic inflammatory disease
• Pancreatitis
• Menstruation
• Uterine fibroids
• Diverticulis
• Lupus
• Abdominal infections

Low CA 125 Level Causes

Decreasing of Ca 125 means the cancer treatment is successful.


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